Research Publications


  • Mihailescu, N., Haskoylu, M. E., Ristoscu, C., Bostan, M. S., Sopronyi, M., Eroğlu, M. S., ... & Mihailescu, I. N. (2018). Gradient multifunctional biopolymer thin film assemblies synthesized by Combinatorial MAPLE. Applied Surface Science.
  • Ozdemir, S., Kilinc, E., & Oner, E. T. (2018). Preconcentrations and determinations of copper, nickel and lead in baby food samples employing Coprinus Silvaticus immobilized multi-walled carbon nanotube as solid phase sorbent. Food Chemistry.
  • Kırtel, O., Versluys, M., Van den Ende, W., & Öner, E. T. (2018). Fructans of the saline world. Biotechnology Advances.
  • Kirtel, O., Menéndez, C., Versluys, M., Van den Ende, W., Hernández, L., & Öner, E. T. (2018). Levansucrase from Halomonas smyrnensis AAD6 T: first halophilic GH-J clan enzyme recombinantly expressed, purified, and characterized. Applied microbiology and biotechnology102(21), 9207-9220.
  • Tohme, S., Hacıosmanoğlu, G. G., Eroğlu, M. S., Kasavi, C., Genç, S., Can, Z. S., & Oner, E. T. (2018). Halomonas smyrnensis as a cell factory for co-production of PHB and levan. International journal of biological macromolecules118, 1238-1246.
  • Tezgel, N., Zorilla, J., Versluys, M., Oner, E. T., Van Den Ende, W., & Swennen, R. (2018). Fructan and glucan-mediated priming in banana. New Biotechnology44, S101-S102.
  • Yassin, O. A., Can, Z. S., Genc, S., Oner, E. T., & Haciosmanoglu, G. G. (2018). Copper Removal From Ammoniacal Spent Etchant by Using Magnetic Nanoparticles. Environmental Research and Technology1(1), 38-42
  • Gomes, T. D., Caridade, S. G., Sousa, M. P., Azevedo, S., Kandur, M. Y., Öner, E. T., ... & Mano, J. F. (2018). Adhesive free-standing multilayer films containing sulfated levan for biomedical applications. Acta biomaterialia69, 183-195.
  • Avsar, G., Agirbasli, D., Agirbasli, M. A., Gunduz, O., & Oner, E. T. (2018). Levan based Fibrous Scaffolds Electrospun via Co-axial and Single-Needle Techniques for Tissue Engineering Applications. Carbohydrate Polymers.
  • Aydogdu, M. O., Chou, J., Altun, E., Ekren, N., Cakmak, S., Eroglu, M., Kutlu O., Toksoy Oner E., Avşar G., Oktar, F. N., Yılmaz I., Günduz O.  (2018). Production of the biomimetic small diameter blood vessels for cardiovascular tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-13.
  • Aydin, B., Ozer, T., Oner, E. T., & Arga, K. Y. (2018). The Genome-Based Metabolic Systems Engineering to Boost Levan Production in a Halophilic Bacterial Model. OMICS: A Journal of Integrative Biology22(3), 198-209.


  • Versluys M., Kirtel O., Öner E. T.,  Ende, W. V. (2017) The Fructan Syndrome: Evolutionary Aspects and Common Themes Among Plants and Microbes. Plant, cell & environment.
  • Queiroz E. A., Fortes Z. B., da Cunha M. A., Sarilmiser H. K., Dekker A. M. B., Öner, E. T., Dekker R.F.H., Khaper, N. Levan promotes antiproliferative and pro-apoptotic effects in MCF-7 breast cancer cells mediated by oxidative stress. International Journal of Biological Macromolecules102, 565-570 (2017).
  • Sezer A. D., Kazak Sarılmışer H., Rayaman E., Çevikbaş A., Öner E. T.,  Akbuğa, J.  Development and characterization of vancomycin-loaded levan-based microparticular system for drug delivery. Pharmaceutical development and technology22(5), 627-634.(2017).
  • Berg, A., Oner, E. T., Combie, J., Schneider, B., Ellinger, R., Weisser, J., ... & Schnabelrauch, M. (2017). Formation of new, cytocompatible hydrogels based on photochemically crosslinkable levan methacrylates. International journal of biological macromolecules.
  • Mutlu, E. C., Bostan, M. S., Bahadori, F., Oner, E. T., & Eroglu, M. S. (2017). An Alternative Nano Design Strategy by Neutralized AMPS and Soy Bean Lecithin to Form Nanoparticles. World Academy of Science, Engineering and Technology, International Journal of Chemical and Molecular Engineering4(6).
  • S Eroglu, M., Toksoy Oner, E., Cansever Mutlu, E., & Sennaroglu Bostan, M. (2017). Sugar Based Biopolymers in Nanomedicine; New Emerging Era for Cancer Imaging and Therapy. Current topics in medicinal chemistry17(13), 1507-1520.
  • Osman, A., Oner, E. T., & Eroglu, M. S. (2017). Novel levan and pNIPA temperature sensitive hydrogels for 5-ASA controlled release. Carbohydrate Polymers165, 61-70.


  • Abbamondi GR, Suner S, Cutignano A, Grauso L, Nicolaus B, Toksoy Oner E, Tommonaro, G. Identification of N-hexadecanoyl-L-homoserine lactone © 16 - AHL) as signal molecule in the halophilic bacterium Halomonas smyrnensis AAD6. Annals of Microbiology 02/2016; DOI: 10.1007/s13213-016-1206-6.
  • Öner, E. T., Hernández, L., & Combie, J. (2016). Review of levan polysaccharide: from a century of past experiences to future prospects. Biotechnology advances34(5), 827-844.
  • Erginer, M., Akcay, A., Coskunkan, B., Morova, T., Rende, D., Bucak, S., ... & Oner, E. T. (2016). Sulfated levan from Halomonas smyrnensis as a bioactive, heparin-mimetic glycan for cardiac tissue engineering applications. Carbohydrate polymers149, 289-296.
  • Mutlu, E. C., Bostan, M. S., Bahadori, F., Kocyigit, A., Oner, E. T., & Eroglu, M. S. (2016). Lecithin‐acrylamido‐2‐methylpropane sulfonate based crosslinked phospholipid nanoparticles as drug carrier. Journal of Applied Polymer Science133(42).


  • Ceyda Kasavi, Serpil Eraslan, Ebru T Oner, Betul Kirdar: An integrative analysis of transcriptomic response of ethanol tolerant strains to ethanol in Saccharomyces cerevisiae. Molecular BioSystems 01/2015;  DOI:10.1039/C5MB00622H.
  • Ali Demir Sezer, Hande Kazak Sarılmışer, Erkan Rayaman, Adile Çevikbaş, Ebru Toksoy Öner, Jülide Akbuğa: Development and characterization of vancomycin-loaded levan-based microparticular system for drug delivery. Pharmaceutical Development and Technology 11/2015;  DOI:10.3109/10837450.2015.1116564.
  • Kasavi C., Eraslan, S., Toksoy Oner E., and Kırdar B."The global transcriptional response of a raw starch degrading amylolytic Saccharomyces cerevisiae strain to oxygen limitation and genetic modification" Turkish Journal of Biology, DOI: 10.3906/biy-1505-6.(2015)
  • Diken, E., Tugba Ozer, Muzaffer Arikan, Zeliha Emrence, Ebru Toksoy Oner, Duran Ustek and Kazim Yalcin Arga."Genomic analysis reveals the biotechnological and industrial potential of levan producing halophilic extremophile, Halomonas smyrnensis AAD6T" SpringerPlus, 4:393  doi:10.1186/s40064-015-1184-3 (2015).
  • Yasar Yildiz S, Radchenkova N, Arga KY, Kambourova M, Toksoy Oner E. "Genomic analysis of Brevibacillus thermoruber 423 reveals its biotechnological and industrial potential" Applied Microbiology and Biotechnology, 1-13. (2015).
  • Sarilmiser Kazak H, Ates O, Ozdemir G, Arga KY, Toksoy Oner E."Effective stimulating factors for microbial levan production by Halomonas smyrnensis AAD6T". Journal of Bioscience and Bioengineering, 119(4):455-63,  (2015).


  • Cansever Mutlu E., Sennaroglu Bostan M., Bahadori F., Kocyigit A., Toksoy Oner E., Eroglu M.S., Lecithin-AMPS-Na+ 2014 Based Paclitaxel Carrier Nanoparticles. (Manuscript 2014)
  •  Sarilmiser Kazak H, Toksoy Oner E, Investigation of anti-cancer activity of linear and aldehyde-activated levan from Halomonas smyrnensis AAD6T. Biochemical Engineering Journal ,92:28-34 (2014). doi: 10.1016/j.bej.2014.06.020
  • Finore I, Donato PD, Poli A, Kirdar B, Kasavi C, Toksoy Oner E., Nicolaus B, Lama L. "Use of Agro Waste Biomass for α-Amylase Production by Anoxybacillus  amylolyticus: Purification and Properties".  J Microb Biochem Technol 6: (2014) 320-326. doi:10.4172/1948-5948.1000162.
  • Arrizon, J., Hernández-Moedano, A., Toksoy-Oner, E., González-Avila, M. "In vitro prebiotic activity of fructans with different fructosyl linkage for symbiotics elaboration". International Journal of probiotics and prebiotics, (in press).
  • Kasavi C, Eraslan S, Arga KY, Toksoy Oner E, Kirdar B. A System Based Network Approach to Ethanol Tolerance in Saccharomyces cerevisiae. BMC Systems Biology, 8:90, (2014). doi:10.1186/s12918-014-0090-6.
  • Axente E. Sima F, Sima L , Erginer M, Eroğlu M. S, Serban N, Ristoscu C, Petrescu S, Toksoy Oner  E, Mihailescu I. N, Combinatorial MAPLE gradient thin film assemblies signalling to human osteoblasts, Biofabrication, 28;6(3):035010 (2014).
  • Sennaroglu Bostan M, Esra Cansever Mutlu, Hande Kazak, S. Sinan Keskin, Ebru Toksoy Oner, Mehmet S. Eroglu Comprehensive characterization of chitosan/PEO/levan ternary blend films, Carbohydrate Polymers, 102:993-1000 (2014).
  • Cansever Mutlu E., Bahadori F., Kazak Sarilmiser H., Toksoy Oner E., Eroglu M.S. Levan Coated Nano Particles For Tumor 
Targeting Delivery. in 2nd International Conferance On Biological & Biomimetic Adhesives. Istanbul (Poster Presentation) 2014 


  • Agirbasli, M., Mesut Eren, Songul Yasar, Kenan Delil, Fatih Goktay, Ebru Toksoy Oner, Douglas E Vaughan Functionally stable plasminogen activator inhibitör-1 in a family with cardiovascular disease and vitiligo. Journal of Thrombosis and Thrombolysis DOI: 10.1007/s11239-013-1021-x (2013).
  • Yasar Yildiz S., Margarita Kambourova, Arga KY, Ebru Toksoy Oner, Draft Genome Sequence of Exopolysaccharide-Producing Thermophilic Bacterium Brevibacillus thermoruber Strain 423. Genome announcements ASM, doi: 10.1128/genomeA. 00774-13 (2013).
  • Yasar Yildiz S., Gianluca Anzelmo, Tugba Ozer, Nadia Radchenkova, Seval Genc, Paola Di Donato, Barbara Nicolaus, Ebru Toksoy Oner, Margarita Kambourova, Brevibacillus themoruber: A Promising Microbial Cell Factory for EPS Production. Journal of Applied Microbiology doi: 10.1111/jam.12362 (2013).
  • Ateş, Ö., Arga KY, Toksoy Öner, E., The stimulatory effect of mannitol on levan biosynthesis: lessons from metabolic systems analysis of Halomonas smyrnensis AAD6(T.) Biotechnology Progress 29(6):1386-97 (2013).
  • Costa, R. R., Neto, A. I., Calgeris, I., Correia, C. R., Pinho, A. C., Fonseca, J., E. Toksoy Oner  ve Mano, J. F. Adhesive nanostructured multilayer films using a bacterial exopolysaccharide for biomedical applications. Journal of Materials Chemistry B., 1, 2367-2374 (2013).
  • Ateş Ö, Arga KY, Toksoy Öner E. The stimulatory effect of mannitol on levan biosynthesis: lessons from metabolic systems analysis of Halomonas smyrnensis AAD6. Biotechnology Progress, 2013. doi:10.1002/btpr.1823.


  • Sima, F., Axente, E., Sima, L.E., Tuyel, U., Eroglu, M.S., Serban, N., Ristoscu, C., Petrescu, S.M.,  Toksoy Oner, E., Mihailescu, I.N. Combinatorial matrix-assisted pulsed laser evaporation: Single-step synthesis of biopolymer compositional gradient thin film assemblies. Applied Physics Letters, 101, 233705 (2012).
  • Kasavi, C., I. Finore, L. Lama, B. Nicolaus, S.G. Oliver, E. Toksoy Oner, B. Kirdar. Evaluation of Industrial Saccharomyces cerevisiae Strains for Ethanol Production from Biomass. Biomass and Bioenergy, 45, 230-238, (2012).
  • Sogutcu, E., Zeliha Emrence, Muzaffer Arikan, Aris Cakiris, Neslihan Abaci, Ebru Toksoy Oner, Duran Ustek, ve Kazim Arga. Draft Genome of Halomonas smyrnensis AAD6T . Journal of Bacteriology, 194 (20), 5690-5691, (2012).
  • Sogutcu E, Emrence Z, Arikan M, Cakiris A, Abaci N, Toksoy Öner E, Üstek D, Arga KY. Draft genome sequence of Halomonas smyrnensis AAD6. J. Bacteriology, 194(20):5690, 2012.doi:10.1128/JB.00559-12.
  • Eroglu M. S., Mutlu E., Sennaroglu Bostan M., Toksoy Oner E. The Effect of Levan on the Morphological and Mechanical Properties of Chitosan Polyethyleneoxide Blend Films. 9th World Biomaterials Congress. Chengdu, 3 China (Poster Presentation) 2012


  • Sima, F., Esra Cansever Mutlu, Mehmet S. Eroglu, Livia E. Sima, L.E., Serban, N.; Carmen Ristoscu, Stefana M. Petrescu, Ebru Toksoy Oner, Ion N. Mihailescu, Levan Nanostructured Thin Films by MAPLE Assembling, Biomacromolecules, 12, 2251–2256, (2011).
  • Finore, İ., Ceyda Kasavi, Annarita Poli, Ida Romano, Ebru Toksoy Oner, Betul Kirdar, Laura Dipasquale, Barbara Nicolaus , Licia Lama, “Purification, biochemical characterization and gene sequencing of a thermostable raw starch digesting α-amylase from Geobacillus thermoleovorans subsp. stromboliensis subsp. nov.” World Journal of Microbiology and Biotechnology, 27 (10), 2425-2433 (2011).
  • Ateş, Ö., Toksoy Öner, E., Arga KY, “Genome-scale Reconstruction of Metabolic Network for a Halophilic Extremophile, Chromohalobacter salexigens DSM 3043” BMC Systems Biology, 5:12 (2011).
  • Küçükaşık, F., Kazak, H., Güney, D., Finore, I., Poli, A., Yenigün, O., Nicolaus, B., Toksoy Öner, E. “Molasses as Fermentation Substrate for Levan production by Halomonas sp.” Applied Microbiology and Biotechnology, 89, 1729-1740 (2011).
  • Sezer A.D., Kazak, H., Toksoy Oner, E., Akbuğa, J. “Levan-based nanocarrier system for peptide and protein drug delivery: Optimization and influence of experimental parameters on the nanoparticle characteristics” Carbohydrate Polymers, 84 (1), 358-363 (2011).
  • Sam S., Kucukasik F., Yenigun O. ,Nicolaus B. ,Toksoy Oner E., Yukselen M. A. "Flocculating Performances of Exopolysaccharides Produced by a Halophilic Bacterial Strain Cultivated on Agro-industrial Waste ", Bioresource Technology, 102 (2), 1788-1794 (2011).
  • Ates Ö, Toksoy Öner E, Arga KY. Genome-scale reconstruction of metabolic network for a halophilic extremophile, Chromohalobacter salexigens DSM 3043. BMC Systems Biology, 5:12, 2011.doi:10.1186/1752-0509-5-12

2010 and earlier

  • Sima F. Cansever Mutlu E., Eroglu M. S., Sima L.E. , Serban N. , Ristoscu C. , Petrescu S.M. Toksoy Oner E., Mihailescu I. Levan thin films by MAPLE. 9th World Biomaterials Congress. Chengdu, China (Poster Presentation) 2012 

Toksoy Oner E., Mutlu E., (2010) A Promising Bioglue from An Extremophile. COST TD0906 Workshop, Biological 
Adhesives: from biology to biomimetics. Vien, Austria (Oral Presentation) 2010
  • Barbara Nicolaus, Margarita Kambourova ve Ebru Toksoy Oner. "Exopolysaccharides from extremophiles: From fundamentals to biotechnology".Enviromental Technology, 31 (10), 1145-1158 (2010).
  • Poli, A., Kazak, H., Gürleyendağ, B., Tommonaro, G., Pieretti, G., Toksoy Öner, E., Nicolaus, B., “High level synthesis of levan by a novel Halomonas species growing on defined media”, Carbohydrate Polymers, 78, 651-657 (2009).
  • Köşebent, D., Ateş, Ö., Toksoy Öner, E., Oliver, S. G., Kırdar, B., “ Fermentation Performances of Amylolytic Saccharomyces cerevisiae Integrands Developed for Bioethanol Production”, New Biotechnology, 25:1, S262, (2009).
  • Günay, M.E., Nikerel, İ.E., Toksoy Öner, E., Kırdar, B. ve R. Yıldırım, Simultaneous modeling of enzyme production and biomass growth in recombinant Escherichia coli using artificial neural networks,” Biochemical Engineering Journal, 42, 329-335 (2008).
  • Nikerel, E., Ateş, Ö. ve Toksoy Öner, E “Effect of Bioprocess Conditions on Growth and Alkaline Protease Production by Halotolerant Bacillus licheniformis BA17”, Applied Biochemistry and Microbiology, 44 (5) 487–492 (2008).
  • Hismiogullari, S.E., Hismiogullari, A.A., F. Sahin, E. Toksoy Oner, S. Yenice ve D. Karasartova “Investigation of Antibacterial and Cytotoxic Effects of Organic Acids Including Ascorbic Acid, Lactic Acid and Acetic Acids on Mammalian Cells”, Journal of Animal and Veterinary Advances 7 (6): 886-889 (2008).
  • Ateş, Ö., Toksoy Öner, E., Arıkan, B., Denizci, A.A., Kazan, D. “Isolation and identification of alkaline protease producer halotolerant Bacillus licheniformis strain BA17”, Annals of Microbiology, 57 (3) 369-375 (2007).
  • Mısırtlı, Z, Toksoy Öner , E. ve B. Kirdar, “Real Imaging and Size Values of Saccharomyces cerevisiae Cells with Comparable Contrast Tuning to Two ESEM-modes”, Scanning, 29, 11 – 19 (2007).
  • Taymaz, H., Erarslan, S., Toksoy Öner, E., Alkan T., Agirbasli, M ve B. Kırdar, “Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population,” Thrombosis Research, 119, 55-62 (2007). 
  • Nikerel, İ.E., Toksoy Öner, E., Yıldırım, R ve B. Kirdar, “Optimization of Medium Composition for Biomass Production of Recombinant Escherichia coli Cells Using Response Surface Methodology,” Biochemical Engineering Journal, 32, 1-6 (2006).
  • Toksoy Öner, E., Optimization of Ethanol Production from Starch by an Amylolytic Nuclear Petite Saccharomyces cerevisiae Strain,” Yeast, 23, 849-856 (2006).
  • Toksoy Öner, E., Oliver S.G. ve B. Kırdar, “Production of Ethanol from Starch by Respiration-Deficient Recombinant Saccharomyces cerevisiae,Applied and Environmental Microbiology, 71, 6443-6445 (2005).
  • Nikerel, İ.E., Toksoy Öner, E., Yıldırım, R ve B. Kirdar, “Optimizing Medium Composition for TaqI endonuclease Production by Recombinant Escherichia coli Cells Using Response Surface Methodology,” Process Biochemistry, 40, 1633-1639 (2005).
  • Toksoy-Öner, E., Kırdar B., Önsan Z.I. ve K. Ülgen, “Modeling of the Induced Expression for  High-level Production of a Foreign Protein by Recombinant E. coli Under the Control of T7 Phage Promoter,”  Process Biochemistry, 39, 315-323 (2003). 
  • Toksoy, E., Önsan Z.I. ve B. Kırdar, “High-level Production of Taq I Restriction Endonuclease by Three Different Expression Systems in Escherichia coli Cells Using T7 Phage Promoter,” Applied Microbiology and Biotechnology, 59, 239-245 (2002).
  • Toksoy, E., Önsan Z.I. ve B. Kırdar, “Expression of a Thermostable Restriction Endonuclease in Recombinant Escherichia coli Cells and Optimization of Fermentation Conditions,” World Journal of Microbiology and Biotechnology, 18, 23-27 (2002).
  • Toksoy, E., Önsan Z.I. ve B. Kırdar, “Effect of the Co-Expression of Methyltransferase Activity on Extracellular Production of Taq I Restriction Endonuclease in Recombinant E. coli Cells,” Process Biochemistry, 37, 527-534 (2001).
  • Toksoy, E., P. H. Özdinler, Z. I. Önsan ve B. Kirdar, “High Level Secretion of Taq I Restriction Endonuclease by Recombinant Escherichia coli,Biotechnology Techniques, 13, 803-808 (1999).


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